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KMID : 1007519990080040232
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Food Science and Biotechnology
1999 Volume.8 No. 4 p.232 ~ p.237
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Antitumor Activities of Extracts and Lectin from Viscum album L . and Viscum album var . coloratum on Cultured HL - 60 Cells
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Kim, Jung Hee
Ham, Seung Shi/Park, Won Bong/Choung, Bo Yeun/Park, Sun Myo/Lee, Taik Soo
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Abstract
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Treatment with scum album L., the white berry European mistletoe, is one of the most widely used alternative cancer therapies in Europe. The yellow berry mistletoe, scum album var. coloratum, grows on oak (Quercus genus) and is distributed widely over the Korean peninsula and partially in China. In this study, with scum album L. collected in Europe and Viscum album L. vac coloratum collected in Korea and in China, the components and biological activities of the plants have been investigated. The aqueous extract of Korean mistletoe showed the highest activities (16 HU) of hemagglutination and cytotoxicity (IC_(50), 1 ㎍/mL) and the aqueous extract of the Chinese variety showed no hemagglutination and the lowest cytotoxicity (IC_(50), 40 ㎍/mL). The results indicate that the lectin and the harvesting area are important for exerting biological activities. Comparing the higher cytotoxicity (14 ng/mL) with the lower hemagglutinating activity (64 HU) of lectin in European mistletoe, the lectins in European mistletoe would be different from lectins in scum album var. coloratum and significant for exerting biological activity. The fraction from European mistletoe showed the lowest activity (IC_(50), 66 ㎍/mL) among the samples. Considering the fact that no lectin was contained in the methanol fraction of mistletoe tested, the low molecular weight components in the extract may play a role in the cytotoxicity of mistletoes.
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